|Probability of malignancy in SPN in patients with previous malignancy|
|A frequent problem is a SPN in a patient with a history of a previous malignancy. As with any nodule, treatment depends on whether the nodule is benign or malignant. In patients with prior malignancy, intuitively the odds that the lesion is a metastasis increases. Whether the nodule is a metastasis or a new primary is also important in treatment|
Determining Risk of Malignancy: Likelihood ratios
Likelihood ratios are intuitive measures of the diagnostic information provided by a test result or clinical finding. The likelihood ratio varies from zero to infinity, depending on the degree of strength of the test result. A test strongly suggestive of aortic rupture has a likelihood ratio much greater than one, a test that suggests no rupture has a likelihood ratio close to zero, and a test that contains no diagnostic information has a likelihood ratio of one. In the odds-likelihood ratio form of Bayes theorem, the odds that the aorta is ruptured is the product of the likelihood ratios favoring aortic rupture multiplied by the prior odds of aortic rupture.
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